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5 percent of digestive-system cancers in the united states, with an estimated 3400 new cases in 2000. It is increased in hiv infection and in patients taking immunosuppressive drugs for hiv infection. Women with a history of cervical cancer or cervical intraepithelial neoplasia (cin) are also known to have a greater risk for anal cancer 3 . Carcinoma of anal canal is usually squamous cell carcinoma and has shown significant association with human papillomavirus. The tumors can be broadly classified into anal cancer and anal margin. Squamous cell carcinomas in the anal canal have grown beyond the surface and into the deeper layers of the lining (as opposed to carcinoma in situ which is only in the surface cells). Cloacogenic carcinomas (also called basaloid or transitional cell carcinomas ) are a type of squamous cell cancer. anal squamous cell carcinoma (scc) is a rare cancer and accounts for approximately 4 of all cancers of the lower alimentary tract. The dominant etiology is infection with human papilloma virus (hpv), which is the most common sexually transmitted disease in the united states.